How to Get Your Insulin to a Normal Level | Ralph DeFronzo
The discussion focuses on managing insulin resistance in type 2 diabetes through lifestyle changes and medication adjustments.
How to Get Your Insulin to a Normal Level | Ralph DeFronzo
Hyperinsulinemia can induce insulin resistance even in healthy individuals.
Peter Attia’s Definition of Longevity
The discussion focuses on the concept of longevity, emphasizing both lifespan and healthspan, and the importance of quality of life over mere longevity.
342 ‒ Aging well: Peter shares strategies for improving longevity with residents at senior living
The discussion emphasizes the importance of exercise, nutrition, sleep, and emotional health in promoting longevity and quality of life.
How to Get Off of Sleep Medication | Ashley Mason, Ph.D.
The discussion focuses on managing sleep medication withdrawal through a slow, precise tapering process, emphasizing psychological support and stability.
How to Get Off of Sleep Medication | Ashley Mason, Ph.D.
The discussion focuses on the impact of sleep supplements and medications, emphasizing the need to understand individual body responses and the risks of dependency.
CBT-I Explained: The Proven Method to Cure Insomnia Without Medication | Ashley Mason, Ph.D.
CBTI focuses on associating the bed only with sleep and sex, and restricting time in bed to improve sleep quality.
CBT-I Explained: The Proven Method to Cure Insomnia Without Medication | Ashley Mason, Ph.D.
Cognitive Behavioral Therapy for Insomnia (CBTI) uses stimulus control and time-in-bed restriction to improve sleep by associating the bed only with sleep and limiting time spent in bed to actual sleep needs.
Social Jet Lag: How to Balance Sleep & Social Life | Ashley Mason, Ph.D.
The discussion focuses on managing social jet lag by maintaining consistent sleep schedules, even on weekends, to improve sleep quality and overall well-being.
Social Jet Lag: How to Balance Sleep & Social Life | Ashley Mason, Ph.D.
The discussion focuses on managing social jet lag by balancing weekend sleep schedules to maintain overall sleep health.
Sleep Hygiene 101: The Best (and Worst) Habits for Better Sleep | Ashley Mason, Ph.D.
The discussion focuses on sleep hygiene, emphasizing room temperature, light exposure, and the impact of blue light on sleep quality.
Sleep Hygiene 101: The Best (and Worst) Habits for Better Sleep | Ashley Mason, Ph.D.
The discussion focuses on optimizing sleep hygiene through temperature control, light management, and minimizing blue light exposure, emphasizing practical solutions like using eye masks and managing caffeine intake.
Time-in-Bed Restriction Explained: How to Reprogram Your Sleep | Ashley Mason, Ph.D.
The discussion focuses on the implementation of Cognitive Behavioral Therapy for Insomnia (CBTI) and the importance of setting consistent wake times to improve sleep patterns.
Time-in-Bed Restriction Explained: How to Reprogram Your Sleep | Ashley Mason, Ph.D.
The discussion focuses on the implementation of time in bed restriction in CBTI and its adaptation in clinical practice.
How to Fall Asleep & Stay Asleep | Ashley Mason, Ph.D.
The discussion focuses on different types of insomnia and practical techniques to manage sleep issues.
How to Fall Asleep & Stay Asleep | Ashley Mason, Ph.D.
The discussion focuses on cognitive behavioral therapy for insomnia, emphasizing scheduled worry time and temperature regulation as effective interventions.
341 - Overcoming Insomnia | Ashley Mason, Ph.D. - Trailer
The discussion focuses on insomnia, its causes, and practical solutions like managing stress and sleep hygiene.
Healing Through Storytelling: How to Overcome the Past | Jeff English
The discussion focuses on storytelling in therapy, emphasizing the importance of sharing personal experiences and receiving feedback without responding to it.
Healing Through Storytelling: How to Overcome the Past | Jeff English
The discussion focuses on storytelling within a structured framework, emphasizing the importance of sharing personal experiences without feedback interruptions.
Five Ways to Reduce Your Microplastic Exposure | Peter Attia
The speaker discusses strategies to mitigate exposure to microplastics and other harmful particles, emphasizing cost-effective and practical solutions.
Peter Attia's VO₂ Max Training Protocol
The discussion focuses on VO2 max training, emphasizing the importance of proper warm-up and interval training for optimal performance.
Breakthroughs in Belief: How to Transform Your Mindset for Success | Jeff English
The discussion focuses on the transformative power of shattering belief systems and the role of experiential therapy in facilitating personal breakthroughs.
Healthspan: What It Means and Why It Matters to You
The discussion critiques the traditional definition of health span and suggests a more personalized approach.
Healthspan: What It Means and Why It Matters to You
The concept of health span is debated, with some viewing it as a nebulous term, while others see it as a useful way to communicate the goal of extending the healthy period of life.
The Difference Between Shame and Guilt | Jeff English
The discussion differentiates between shame and guilt, emphasizing the importance of recognizing and addressing these emotions for personal growth and healing.
Why are autism rates increasing? | Trenna Sutcliffe and Peter Attia
The prevalence of autism has increased significantly, with environmental factors and genetic predispositions being key contributors.
How is autism spectrum disorder (ASD) diagnosed? | Trenna Sutcliffe and Peter Attia
The diagnosis of autism spectrum disorder (ASD) involves assessing social communication skills and repetitive behaviors, with criteria evolving over time.
What is insulin resistance? | Dr. Ralph DeFronzo
Insulin resistance is a condition where the body's cells don't respond effectively to insulin, affecting glucose uptake and fat metabolism.
Peter’s takeaways on aerobic exercise and VO2 max, insulin resistance, and more (Trailer)
The podcast discusses various health topics, including pharmaceutical advertising, training performance, insulin resistance, healthcare costs, and mental health conditions.
Peter’s takeaways on aerobic exercise and VO2 max, insulin resistance, and more (QPS 4 sneak peek)
The podcast discusses various health and fitness topics, focusing on training performance, insulin resistance, and endurance sports nutrition.
The top drugs for diabetics | Dr. Ralph DeFronzo
The discussion focuses on the effectiveness of newer diabetes drugs, particularly GLP-1 receptor agonists and SGLT2 inhibitors, in managing diabetes and preventing cardiovascular issues.
Pros & cons of GLP-1 weight loss drugs | Dr. Ralph DeFronzo
Concerns about GLP-1 drugs include muscle mass loss during significant weight loss.
Pros & cons of GLP-1 weight loss drugs | Dr. Ralph DeFronzo
The discussion focuses on the safety and effects of GLP-1 receptor agonists and myostatin inhibitors on muscle mass and overall health.
The triple therapy: three free drugs that work better for diabetics | Dr. Ralph DeFronzo
The EDICT study demonstrates that using a triple therapy approach from the onset of diabetes treatment significantly improves patient outcomes compared to traditional methods.
What is causing the current diabetes epidemic? | Dr. Ralph DeFronzo
The discussion explores the multifaceted causes of obesity and diabetes, emphasizing the role of neurocircuitry changes in the brain and genetic predispositions.
Should children be on GLP-1 weight loss drugs? | Dr. Ralph DeFronzo
Childhood obesity leads to lifelong health issues, with current treatments often ineffective for adolescents.
GLP-1 agonists and the willpower myth
Discussion on the use of GP1 agonists for weight management and the role of genetics.
Why strength training is the best time-efficient investment for health | Mike Israetel
Strength training offers significant health benefits with minimal time investment, focusing on high-intensity efforts rather than endurance.
Long-term impacts of steroid use: muscle retention, impact after discontinuation, and more
The discussion focuses on the impact of anabolic steroids on muscle mass and the potential for maintaining gains after stopping use.
Anabolic steroids: effects, risks, and insights | Mike Israetel & Peter Attia
The discussion focuses on the use of anabolic steroids, particularly testosterone, in bodybuilding, highlighting their effects, dosages, and the balance between benefits and side effects.
The importance of nutrition, protein intake, and consistency in training and diet for muscle growth
Genetics, age, and consistency are key factors in achieving fitness goals.
Training plateaus: optimizing exercise selection, intensity, and recovery for muscle growth
The discussion focuses on optimizing muscle growth for experienced weightlifters by addressing training variables and realistic expectations.
Fasting, well-balanced diets, alcohol, exercise, assessing cardiovascular health (AMA 68 Sneak Peek)
The podcast discusses cardiovascular health assessment, fasting, and alcohol's impact on health.
How statins might affect brain cholesterol synthesis and cognitive function | Tom Dayspring
The discussion focuses on the effects of statins on brain health, particularly cognitive impairment and Alzheimer's disease, and explores alternative lipid-lowering therapies.
Why cholesterol is critical for brain function | Tom Dayspring and Peter Attia
The brain is the most cholesterol-rich organ, synthesizing its own cholesterol, which is crucial for neuron function and myelin production.
The limitations of using HDL cholesterol as a marker for heart health | Tom Dayspring
HDL cholesterol levels do not reliably indicate cardiovascular health due to the complex functionality of HDL particles.
How to find a good personal trainer | Mike Israetel and Peter Attia
Finding a good trainer involves evaluating their qualifications, understanding of science, and personal compatibility.
Simple and effective 2-day strength training program for beginners | Mike Israetel and Peter Attia
The discussion focuses on creating an efficient resistance training program for beginners, emphasizing compound movements and time management.
Should you start your workout with cardio or strength training?
The order of cardio and resistance training depends on personal goals and workout intensity.
Why you should get a colonoscopy and what to ask your doctor when it’s over
The speaker shares insights on colonoscopy procedures and highlights issues with healthcare costs.
Reframing: emotional health benefits and examples of how to use it
Reframing can transform irritation into appreciation by shifting perspective.
Why rate of perceived exertion (RPE) is the best metric for identifying Zone 2 training
Rate of perceived exertion is crucial for determining training zones, more so than heart rate or lactate levels.
How aging and lifestyle factors contribute to rising ApoB and LDL cholesterol levels
The discussion focuses on how lifestyle and diet impact LDL cholesterol levels and the role of the liver in regulating these levels.
Why ASCVD is a silent killer and how early detection can save your life | Tom Dayspring
Atherosclerosis is a leading cause of death, developing slowly from childhood, with early detection and prevention being crucial.
Defining atherosclerotic cardiovascular disease (ASCVD): development, risks, & physiological impact
The discussion focuses on atherosclerotic cardiovascular disease, emphasizing the deposition of cholesterol in artery walls and its impact on blood flow, particularly in small arteries supplying the heart and brain.
Do resveratrol and NAD precursors promote longevity?
The discussion critiques the efficacy of Resveratrol and NAD precursors in extending lifespan and improving health.
Do GLP-1 receptor agonists like Ozempic and Wegovy help slow aging or increase lifespan?
Discussion on the potential geroprotective effects of GLP-1 agonists and challenges in testing them.
Does exercise slow aging?
Exercise improves healthspan significantly, though its impact on lifespan is less clear.
The difference between biologic and chronologic age
The discussion explores the concept of biological versus chronological age, questioning the validity and usefulness of biological age measurements.
Proactive healthcare: rethinking health, disease, and the role of aging
The discussion emphasizes shifting from reactive to proactive healthcare, focusing on aging biology to prevent diseases like cancer.
Defining healthspan and why the US struggles with life expectancy despite high healthcare spending
The U.S. has low life expectancy despite high healthcare spending, with a focus on extending life rather than improving health span.
Nature vs. nurture's impact on longevity | Nir Barzilai and Peter Attia
The discussion explores the impact of genetics and environment on lifespan, questioning if perfect genes can be offset by poor lifestyle choices.
What is healthspan? | Nir Barzilai and Peter Attia
The discussion highlights the inadequacy of current health span metrics and the need for better definitions and understanding of health span, particularly in aging populations.
Body weight set points: why maintaining weight loss is so difficult | Stephan Guyenet
The discussion explores weight loss, set points, and the impact of environment and genetics on obesity.
The relationship between protein intake and aging | Matt Kaeberlein and Peter Attia
The discussion focuses on protein intake, its impact on muscle synthesis, and its role in aging, highlighting the importance of protein distribution and the effects of protein restriction in animal studies.
Caloric restriction's impact on muscle mass, strength, and the immune system | Matt Kaeberlein
The discussion explores the effects of caloric restriction (CR) on laboratory animals, particularly its impact on the immune system and aging, and the challenges of applying these findings to humans.
What are epigenetic clocks used for? | Matt Kaeberlein and Peter Attia
The discussion explores the utility and skepticism surrounding epigenetic clocks in measuring biological aging.
Microplastics, PFAS, and phthalates: health risks & minimizing exposure (AMA 67 sneak peek)
The podcast discusses the growing concern over microplastics and other chemicals like BPA and phthalates, exploring their definitions, exposure routes, and health implications.
The link between cardiorespiratory fitness and brain health | Rhonda Patrick and Peter Attia
Higher physical fitness significantly reduces dementia risk, with objective measures like VO2 Max showing the strongest correlation.
Exercise: the key to improving all aspects of health | Rhonda Patrick and Peter Attia
Exercise is the most effective way to reduce the risk of various diseases, including cancer and Alzheimer's.
Supplements that can improve VO₂ max | Olav Aleksander Bu and Peter Attia
Beetroot and nitrate supplements can boost V2 Max by improving blood flow, but effects vary between amateur and elite athletes.
What you should know before taking a VO₂ max test | Olav Aleksander Bu and Peter Attia
The discussion focuses on optimizing VO2 max testing and common mistakes to avoid for accurate results.
Defining and understanding VO₂ max | Olav Aleksander Bu and Peter Attia
The discussion focuses on VO2 Max, its measurement, and factors affecting it.
Does the average person need to lift in low-rep ranges? | Layne Norton and Peter Attia
Strength training can be effective with higher rep ranges and doesn't always require low reps unless training for specific strength sports.
What does science tell us about the carnivore diet? | Stephan Guyenet and Peter Attia
The carnivore diet is discussed for its weight loss potential and health implications, with concerns about high LDL cholesterol levels.
Common questions about medicating children with ADHD: benefits, side effects, dosage, and more
Parents often regret delaying psychiatric medication for children due to quick positive effects.
Advice for parents trying to find and evaluate care for children with autism, ADHD, or anxiety
Parents should seek personalized, multidisciplinary care for children with conditions like anxiety, ADHD, or ASD, starting with their pediatrician and building a supportive team.
The overlap between Autism Spectrum Disorder, ADHD, and anxiety | Trenna Sutcliffe and Peter Attia
The discussion focuses on the overlap between ASD, ADHD, and anxiety in children, highlighting significant comorbidity rates and diagnostic challenges.
How is Autism Spectrum Disorder diagnosed? | Trenna Sutcliffe and Peter Attia
The diagnosis of autism spectrum disorder (ASD) involves assessing social communication skills and repetitive behaviors, with criteria evolving over time.
Signs of anxiety and ADHD to look for in your children | Trenna Sutcliffe and Peter Attia
The discussion focuses on understanding different types of anxiety in children and how to identify them based on impairment and impact on daily functioning.
Why older people are more negatively impacted by sugar consumption | Peter Attia and Rick Johnson
Aging and menopause affect glucose sensitivity due to changes in mitochondrial health and uric acid levels.
How we are hard-wired to think about food | Peter Attia & Stephan Guyenet
The discussion explores how human ancestors prioritized calorically dense foods through subconscious mechanisms and dopamine-mediated reinforcement, focusing on nutrients like carbohydrates, fats, proteins, and sodium.
Layne Norton's views on low-carb diets and the tribal nature of nutrition | Peter Attia
The speaker discusses the polarization around low-carb diets and emphasizes the importance of personal preference in diet choices.
Why humans evolved to gain fat so easily | Peter Attia & Stephan Guyenet
The discussion explores the evolutionary importance of energy storage in humans, emphasizing the role of fat as a critical energy reserve.
Genetics and obesity: how much is predetermined? | Peter Attia & Stephan Guyenet
Obesity is highly heritable, with genetics playing a significant role in body mass index (BMI) variations.
Are all calories created equal? | Peter Attia and Rick Johnson
Fructose consumption can lead to weight gain by increasing appetite and reducing energy expenditure.
Where does high intensity interval training fit into a healthy exercise program? | Alex Hutchinson
High-intensity interval training (HIIT) is effective for health and performance but should be part of a balanced exercise routine.
Keys to avoiding injuries during exercise | Peter Attia and Alex Hutchinson
The discussion focuses on injury prevention, emphasizing the importance of gradual training increases and monitoring training loads to avoid overuse injuries.
The most promising interventions for addressing obesity and improving public health | David Allison
General education, especially for women, can reduce obesity and diabetes rates.
Why it's critical to build muscle mass and aerobic capacity in middle age | Alex Hutchinson
The discussion focuses on maintaining fitness and muscle mass as one ages, emphasizing the importance of avoiding inactivity to prevent rapid decline.
Practical tips for changing habits | Peter Attia and James Clear
The discussion focuses on habit formation and breaking, emphasizing the importance of environment and incremental changes.
What is VO₂ max and why does it matter? | Peter Attia and Alex Hutchinson
The discussion focuses on VO2 max, its significance in endurance sports, and the physiological factors affecting it.
The relationship between muscle size and muscle strength | Peter Attia and Jeremy Loenneke
The relationship between muscle strength and hypertrophy is complex, with traditional views suggesting a causal link, but recent research questioning this assumption.
Why high sodium diets can increase the risk of obesity, hypertension, and metabolic syndrome
High salt intake stimulates fructose production in the body, contributing to obesity and metabolic syndrome.
Defining strength and hypertrophy | Peter Attia and Jeremy Loenneke
The discussion focuses on understanding muscle hypertrophy and strength, emphasizing the role of neurological changes and muscle fiber size in strength gains.
Dietary strategies to reduce the negative impact of fructose | Peter Attia and Rick Johnson
The discussion focuses on managing fructose intake and its implications for health, emphasizing the importance of reducing sugary drinks and understanding the fructose content in fruits.
Understanding fast-twitch and slow-twitch muscle fibers | Peter Attia and Jeremy Loenneke
The discussion explores the complexity of muscle fiber types and their genetic and training influences on athletic performance.
Most promising molecules for longevity | Peter Attia and Steve Austad
The discussion focuses on the potential of existing molecules like metformin and rapamycin for geroprotection, emphasizing the need for human trials and the challenges in translating mouse data to human applications.
Peter on exercise, important labs, building good habits, longevity research (Special AMA sneak peek)
The podcast discusses the importance of grip strength, exercise strategies, and considerations for maintaining fitness while traveling.
What is Lp(a) and what is its relationship with cardiovascular disease risk? | Benoît Arsenault
The video discusses the epidemiology and measurement challenges of lipoprotein(a) (LPA) and its association with cardiovascular risk.
The impact of ultra-processed foods on energy balance | Peter Attia and Michael Easter
The discussion focuses on the impact of ultra-processed foods on weight gain and the obesity crisis, highlighting a study by Kevin Hall that shows people consume more calories and gain weight when eating ultra-processed foods compared to minimally processed foods.
The crucial functionality of the liver & its four most essential functions | Julia Wattacheril
The liver is a complex and vital organ with over 300 functions, crucial for metabolism, detoxification, and blood glucose regulation.
Why 12-step programs work for addictions | Peter Attia and Anna Lembke
The video discusses the effectiveness and accessibility of 12-step programs for addiction recovery, highlighting their community-driven support and the concept of 'pro-social shame.'
Why are some people more prone to overeating and other excessive behaviors? | Michael Easter
The discussion explores why some people are more susceptible to overconsumption of ultra-processed foods and other addictive behaviors, highlighting the role of emotional eating, stress, and early exposure to addictive substances.
Exploring addiction vulnerability: what roles do nature and nurture play? | Anna Lembke
The discussion explores why different individuals become addicted to various stimuli, despite similar brain pathways, and examines personal experiences with addiction and the factors influencing addiction vulnerability.
Optimizing nutrition for health and longevity (AMA 66 sneak peek)
The podcast episode discusses the complexities of nutrition, its research challenges, and its relationship with health and weight management.
Is a universal Medicare program feasible in the US? | Peter Attia and Saum Sutaria
The discussion explores the challenges and considerations of implementing a universal Medicare program in the U.S., emphasizing the complexities of healthcare costs, choice, and chronic disease management.
Potential solutions and challenges to controlling pharmaceutical drugs costs in the US | Peter Attia
The discussion explores the strengths and challenges of the U.S. healthcare system, particularly focusing on the balance between choice, cost, and quality, and the potential for innovation in drug pricing and healthcare delivery.
Why is life expectancy lower in the US than other developed countries? | Peter Attia & Saum Sutaria
The US has a lower life expectancy compared to other developed nations due to factors like infant mortality, drug overdoses, and violence, but excels in extending life expectancy after age 70 due to advanced healthcare systems.
Why are pharmaceutical drugs so expensive in the US? | Peter Attia and Saum Sutaria
The video discusses the high cost of drugs in the U.S. healthcare system and the role of Pharmacy Benefit Managers (PBMs) in influencing drug prices.
Why is US healthcare so much more expensive than it was in the 1950s? | Peter Attia and Saum Sutaria
The video discusses the evolution of the U.S. economy and healthcare system from the 1950s to the present, highlighting the growth in GDP, healthcare expenditures, and the role of federal government in healthcare.
How the US healthcare system currently works and how we got here | Peter Attia and Saum Sutaria
The video discusses the complexities and financial structure of the U.S. healthcare system, highlighting its high costs and inefficiencies compared to other countries.
327 - Choices, costs, and challenges in US healthcare: insurance, drug pricing, & potential reforms
The podcast discusses the evolution and current state of the U.S. healthcare system, highlighting its complexity, cost, and the challenges of balancing access, choice, and quality with rising expenses.
Advantages of early screening for cancer | Peter Attia and Robert Gatenby
The discussion highlights the importance of early cancer screening, despite challenges, and emphasizes the role of innovative tools and brave oncologists in advancing cancer detection and treatment.
Using the coronary calcium (CAC) score to predict cardiovascular disease risk | Allan Sniderman
The video discusses the coronary artery calcium (CAC) score as a predictive tool for cardiovascular risk, emphasizing its utility and limitations in different age groups.
What causes cancer to spread and metastasize? | Peter Attia and Robert Gatenby
The video discusses the source-sink dynamics in cancer metastasis, highlighting how certain cancers spread to specific organs and the challenges in understanding and treating metastatic cancer.
How the immune system works and why it seems to allow cancer to proliferate
The video discusses the immune system's role in fighting viruses and cancer, highlighting how it detects foreign antigens and the challenges it faces with cancer cells.
Can you increase strength without increasing muscle size? | Peter Attia and Jeremy Loenneke
The video discusses the relationship between muscle growth and strength, suggesting that muscle growth may not be necessary for strength gains, and explores alternative mechanisms like neural adaptations.